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MRI-based assessment of regional patterns of cortical strain in the human brain resulting from non-impact dynamic mechanical loading
Ziying Yin1, Matthew C. Murphy1, Yi Sui1, Armando Manduca2, Richard L. Ehman1, and John III Huston1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States
Local cortical strain would likely reflect the nearby skull-brain tethering that contributes to the brain’s response to head impact. We have developed MRE-based methods to quantify 3D cortical strain under non-impact loading and found that cortical strain distribution is region-dependent.
Fig.2. Examples of OSS and NOSS maps of brain surface from both vertical (AP) and horizontal (LR) vibrations.
Fig.4. Group comparison of cortical NOSS among different brain lobes.