Seong-Eun Kim1, J Scott McNally1, Matthew Alexander1, Dennis L Parker1, Matthew S Zabriskie 1, and Ronald Day2
1UCAIR, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Department of Pediatrics, University of Utah, Salt Lake City, UT, United States
1UCAIR, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Department of Pediatrics, University of Utah, Salt Lake City, UT, United States
Methemoglobin(MetHb) modulated from sodium nitrite has a great potential for an alternative intravenous contrast agent. Our results demonstrated that in vivo MetHb modulation resulted T1 shortening of blood and soft tissue enhancement.
Fig 2. Dynamic T1 map of in vivo MetHb induction at baseline(t=0), t=2, 8, 30 mins after SN treatment and typical ROI selections for mean T1 measurement.
Fig 3. In vivo T1 changes in vascular structures were plotted as a function of time after SN injection. Plots at baseline, and different time delay (4, 8, 12, 14, 16, 20, 26 and 30 minutes) from SN injection from four rabbit studies.