Xiao-Yong Zhang1, Botao Zhao1, Zhe Phillip Sun2, and Yin Wu3
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
We developed a quasi-steady-state (QUASS) CEST method for robust quantification of tumor MT and APT effects by correction of saturation time and
relaxation delay, which may offer
a straightforward
approach to standardize CEST measurements.
Figure 2. Multipool Lorentzian fitting of (a, b) apparent and
(c, d) QUASS Z-spectra in (a, c) contralateral normal tissue and (b, d) tumor
regions with Ts/Td of 2s/2s and 4s/4s, respectively.
Figure 3. Multi-parametric MR images of a representative rat
bearing C6 glioma tumor. (a) T1, (f) R1, apparent CEST
maps of (b, c) MT and (d, e) APT, and QUASS CEST maps of (g, h) MT and (i, j)
APT with Ts/Td of 2s/2s and 4s/4s, respectively.
