0263
Alterations in dynamic functional connectivity in individuals with subjective cognitive decline
Qian Chen1, Jiaming Lu2, Xin Zhang2, Jilei Zhang3, and Bing Zhang1
1Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China, 2Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 3Philips Healthcare, Shanghai, China
Individuals with subjective cognitive decline at higher risk of Alzheimer’s disease showed alterations in temporal properties of fractional windows, mean dwell time, and the number of transitions by dynamic functional connectivity analysis.
Figure 2. The four states identified by k-means clustering analysis and the corresponding cluster centroids. The total number and percentage of reoccurrence times of each state are listed above each cluster (A), together with 5% strongest connections of each state (B). BG: basal ganglia; AUD: auditory; VIS: visual; SMN: sensorimotor; CEN: cognitive executive; DMN: default mode; CB: cerebellar.
Figure 1. Independent components (n = 33) identified by group independent component analysis. (A) Independent component spatial maps divided on the seven functional networks. (B) Group averaged static functional connectivity matrix between pairs of independent components.