Matthew Christopher Murphy1, Petrice M Cogswell1, Joshua D Trzasko1, Armando Manduca2, Matthew L Senjem1, Clifford R Jack, Jr.1, Fredric B Meyer3, Richard L Ehman1, and John Huston, III1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States, 3Neurosurgery, Mayo Clinic, Rochester, MN, United States
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States, 3Neurosurgery, Mayo Clinic, Rochester, MN, United States
A
non-parametric statistical framework is outlined to display the result of brain
MRE exams in terms of an effect size. Using these maps but no summary
statistics, neuoradiologists were able to diagnose normal pressure
hydrocephalus with 70% sensitivity and 100% positive predictive value.
One example set of images per group in the study. The top row shows the
age- and sex-corrected median stiffness map. The bottom row shows the effect
size map.
Example quantile maps at one slice location for a single NPH participant
(top row) and the CU group (bottom row).