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Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate

Mahir Tazwar¹, Arnold M Evia Jr.², Ashish A Tamhane², David A Bennett², Julie A Schneider², and Konstantinos Arfanakis^1,2
¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R₂ in temporal, frontal, occipital lobes and basal ganglia, after controlling for other known age-related neuropathologies and demographics.

Fig. 3. (A) Sagittal slices (arranged from medial to lateral) and (B) axial slices (arranged from superior to inferior) showing regions of significant R₂ shortening associated with LATE-NC. Corrected p-value maps obtained from voxel-wise analysis are shown in blue (p<0.05).