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Does the internal carotid artery attenuate blood-flow pulsatility in small vessel disease? A 7T 4D-flow MRI study.
Rick J. van Tuijl1, Ynte M. Ruigrok2, Irene C. van der Schaaf1, Lennart J. Geurts1, Gabriël J. E. Rinkel2, Birgitta K. Velthuis1, and Jaco J. M. Zwanenburg1
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology, UMC Utrecht, Utrecht, Netherlands
Internal carotid artery calcifications yield lower arterial distensibility and higher blood-flow pulsatility in patients with cerebral small vessel disease. Moreover, pulsatility increases over the siphon in patients, but decreases in controls.
Figure 1: 4D PC MRA visualization of a subject participating in this study using the CAAS software (Pie Medical Imaging). A) Based on the fully automated centerline detection, cross-sections through the different Internal Carotid Artery (ICA) segments, C1-C7,were selected as illustrated by the 7 slices, with matching numbers from 1 till 7. B) Visualized streamlines through the selected planes.
Figure 2: Boxplots showing the median, interquartile range, and minimum-maximum values of the variation in A) velocity Pulsatility Index (vPI); B) Arterial Distensibility (mmHg-1) for patients with cerebral small vessel disease (CSVD) and controls per internal carotid artery (ICA) segment.