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Macromolecular proton fraction mapping based on spin-lock for the non-invasive diagnosis of early stage liver fibrosis

Jian Hou¹, Vincent Wai-Sun Wong², Grace Lai-Hung Wong², Baiyan Jiang¹, Yi-Xiang Wang¹, Anthony Wing-Hung Chan³, Winnie Chiu-Wing Chu¹, and Weitian Chen¹
¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

MPF measured using MPF-SL shows correlations with the degree of liver fibrosis. A significant difference of MPF between normal (F0) and early stage liver fibrosis (F1/F2) was observed.

Figure 1. Example MPF maps, a): from a patient without liver fibrosis (F0), and b): from a patient with fibrosis stage F2. All results were confirmed by liver biopsy.

Figure 2. The box plot of the measured MPF using MPF-SL at stage F0 and stage F1/F2.