Prediction of Overall Survival in Patients with Pancreatic Cancer: Texture Analysis of ADC Value and Correlation with Intratumoral Necrosis
Yoshifumi Noda1, Nobuyuki Kawai1, Hiroyuki Tomita2, Takuma Ishihara3, Yoshiki Tsuboi3, Masaya Kawaguchi1, Tetsuro Kaga1, Fuminori Hyodo4, Akira Hara2, and Masayuki Matsuo1
1Department of Radiology, Gifu University, Gifu, Japan, 2Department of Tumor Pathology, Gifu University, Gifu, Japan, 3Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Japan, 4Department of Frontier Science for imaging, Gifu University, Gifu, Japan
The kurtosis of tumor ADC
values obtained from texture analysis is correlated with massive intratumoral
necrosis and is associated with poor prognosis in patients with pancreatic cancer.
Kaplan–Meier
3-year survival curves for PDACs
with high and low kurtosis values.
Patients with high kurtosis
exhibited lower survival rates than those with low kurtosis (P < 0.001: 1-year survival
rate, 75.2% vs. 100%: 3-year survival rate, 14.7% vs. 100%).
Cox Proportional Hazard Analysis of Prognostic Factors
for Overall Survival