Merel M. van der Thiel1,2, Whitney M. Freeze2,3,4, Joost de Jong1,2, Inez H.G.B. Ramakers2,4, Walter H. Backes1,2,5, and Jacobus F.A. Jansen1,2,6
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health & Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands, 5School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, 6Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health & Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands, 5School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, 6Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
The interstitial fluid fraction is a promising
imaging marker in Alzheimer’s disease. By identifying the M-direction to be essential
for the identification of clinical group differences, this study demonstrates
that acquisition time can be shortened.
Table 3. Clinical group differences in
Dpar, Dint and fint
as calculated from M, P, S and trace images. CON = controls, MCI = mild cognitive impairment, AD = Alzheimer’s
disease, NAWM = normal appearing white matter, CC = Corpus Callosum, Dint =
interstitial fluid diffusion, Dpar = parenchymal diffusion, fint = interstitial
fluid fraction. β represents standardized beta coefficients. Only significant correlations (i.e., p<0.05) are reported. Analyses
were adjusted for age, sex, absolute and relative sum of squares.
Figure 1. A graphic display of the primary imaging directions, M
(measurement direction: left-right, in red), P (phase-encoding direction: anterior-posterior,
in purple) and S (selection direction: superior-inferior, in blue).
