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High-resolution kidney MRI in mice for longitudinal tracking of kidney volume and cyst burden

Florian Schmid¹, Geogios Koukos¹, Yi Liu¹, Matt Sooknah¹, Sandip Chatterjee¹, Adam Freund¹, and Johannes Riegler¹
¹Calico Life Sciences LLC, South San Francisco, CA, United States

We present improved methods for acquisition and data analysis of kidney MRI in mouse models of chronic kidney disease, allowing for higher quality longitudinal tracking of disease progression and cyst development.

Fig. 1: Kidney images with short (left, 25 ms) and long (right, 60 ms) TE of one exemplary animal, showing fine detail, sharp boundaries and good cyst to tissue contrast

Fig. 2: Automatically detected cysts from one exemplary animal (left), histogram of cyst size and total volume of every cyst size (right)