Hyun-Seo Ahn1, Jaeseok Park2, Chul Ho Sohn3, and Sung-Hong Park1
1Department of Bio and Brain Engineering, Korea Advnaced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of
1Department of Bio and Brain Engineering, Korea Advnaced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of
- 1. The proposed multi-slice multi-delay diffusion-weighted ASL provides various quantitative perfusion measures including BBB permeability.
- 2. The water exchange rate in Alzheimer patients were smaller than normal subjects, opposed to common knowledges on BBB permeability.
Fig 3. From top to bottom, cerebral blood
flow, arterial transit time, water exchange rate, arterial blood volume, and
water permeability maps were estimated for 8 slices.
Fig 2. (a) Sequence diagram of proposed 2D
multi-slice multi-delay DWASL. (b) Bipolar diffusion weighting gradient was applied
after slice excitation RF pulse which increased TE by 30ms. (c) Slice
acquisition order was permuted through sets. 8 pairs of control and labeled
image were obtained for each set. Slices of first half were imaged at odd PLDs,
and second half were imaged at even PLDs.