Charith Perera1, Jack Wells1, Ian Harrison1, David Thomas2,3,4, and Mark Lythgoe1
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 3Leonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 4Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 3Leonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 4Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
CO2 induced similar increases in cortical perfusion and the
BCSFB-ASL signal (21%). Caffeine evoked an exclusive, marked decrease in
BCSFB-mediated water exchange (41%). The aged brain displays impaired BCSFB reactivity towards a vasopressin challenge.
Figure 1 - Interleaved-TE ASL data obtained simultaneously for relative cortical perfusion and relative BCSFB-ASL signal. Averaged time courses for relative cortical perfusion (column 1) and the individual animal averages (column 2). Relative BCSFB-ASL signal averaged time courses (column 2) are shown alongside their respective individual animal averages (column 3). Rows represent each drug or challenge: row 1 - CO2 (a-d), row 2 - vasopressin (e-h), row 3 - caffeine (i-l). Further details of the drug challenges can be found in Table 1.
Figure 2 - Adult (n = 14) vs aged (n = 14) response to vasopressin.
a) Relative BCSFB-ASL signal obtained using Interleaved-TE ASL, showing both adult and aged averaged time courses (vasopressin administration at 10 mins).
b) Adult (n = 14) vs aged (n = 14) response to vasopressin, individual animal averages (baseline and post-vasopressin challenge).
