Eddie C. Wong1,2, Xunda Wang1,2, Vick Lau1,2, Alex T.L. Leong1,2, and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China
Here, we revealed that the absence
of hippocampal output disrupts auditory processing of vocalizations . For the first time, our auditory fMRI results demonstrated the critical role of hippocampus in
shaping response selectivity to behaviorally-relevant sounds.
Figure
2. Inactivating hippocampal outputs abolishes response
selectivity to aversive vocalizations in IC, MGB and AC. (A) Illustration of the
atlas-based ROI definitions (Top). Averaged auditory-evoked activation
maps before and after TTX infusion (Bottom). (B) BOLD signal profiles
extracted from the defined ROIs of IC, MGB, and AC (error bars indicate SEM). (C) Averaged BOLD signal
comparison showing the influence of TTX inactivation of vHP on response
selectivity to aversive vocalizations. (Paired two-sample t-test ,* for p <
0.05, and ** for p < 0.01).
Figure
1. (A) Illustrations of TTX infusion
into right vHP. (B) Experimental protocol of auditory fMRI experiments. Standard
block paradigm (20s ON and 40s OFF) was used to present vocalizations to the
left ear. Forward and reversed vocalizations were interleaved during each
auditory fMRI session. (C) The temporal waveform of forward (left)
and temporally reversed (right) aversive vocalizations. (D) The
spectrograms of forward (left) and temporally reversed (right)
aversive vocalizations.