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Twelve-Year Microstructural Changes in The Deep Gray Nuclei in Parkinson’s Disease: A Serial Diffusion Tensor Imaging Study

Yao-Chia Shih^1,2, Qi Rong Leon Ooi³, Septian Hartono^2,3, Thomas Welton^2,3, Hui-Hua Li^2,4, John Carson Allen², Eng King Tan^2,3, and Ling Ling Chan^1,2
¹Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Department of Neurology, National Neuroscience Institute (Outram-campus), Singapore, Singapore, ⁴Health Services Research Unit, Singapore General Hospital, Singapore, Singapore

Widespread deep nuclear neurodegeneration as evidenced by MD increases is seen in late PD stages after 12 years, while FA changes suggested more complex interplay of iron deposition effects and functional re-organization in the putamen and thalamus.

Fig. 1 Schematic of semi-automated tissue segmentation pipeline.

Fig. 2 Temporal FA and MD profiles in the four deep gray nuclei across 12 years. In each line chart, the blue solid line indicates mean DTI metric in healthy controls, whereas the red dotted line indicates mean DTI metrics in PD patients. The upper and row charts refer to FA and MD changes respectively.