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Microstructure of grey matter nuclei in early Parkinson’s disease: longitudinal study using diffusion kurtosis imaging

Thomas Welton^1,2, Septian Hartono³, Yao-Chia Shih³, Samuel Y-E Ng¹, Nicole S Y Chia¹, Weiling Lee³, Say Lee Chong³, Eng-King Tan^1,2,3, Ling-Ling Chan^1,2,3, and Louis CS Tan^1,2
¹National Neuroscience Institute, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Singapore General Hospital, Singapore, Singapore

We found elevated mean kurtosis in specific basal ganglia regions, which was maintained over two years and negatively correlated with worsening motor function in Parkinson’s disease.

Figure 1. (A) Substantia nigra mask (orange region) from the CIT168 atlas. (B) Mean kurtosis in each region of interest compared between groups. Bars show the raw uncorrected data while p-values and adjusted R2 values given are for the corrected model controlling for age, sex and education. (C) Radial plots of diffusion kurtosis indices for each region and both groups. (D) Plots of the estimated marginal means from repeated-measures ANOVA. Error bars show 95%CI. * Significant for p<0.05.