Jianli Wang1, Rachel Stanford1, Lauren Spreen2, Jeffrey Vesek2, Christopher Sica1, Thyagarajan Subramanian3, and Qing X Yang4
1Radiology, Penn State College of Medicine, HERSHEY, PA, United States, 2Molecular Biology, Penn State College of Medicine, HERSHEY, PA, United States, 3Neurology, Penn State College of Medicine, HERSHEY, PA, United States, 4Neurosurgery, Penn State College of Medicine, HERSHEY, PA, United States
1Radiology, Penn State College of Medicine, HERSHEY, PA, United States, 2Molecular Biology, Penn State College of Medicine, HERSHEY, PA, United States, 3Neurology, Penn State College of Medicine, HERSHEY, PA, United States, 4Neurosurgery, Penn State College of Medicine, HERSHEY, PA, United States
In this study, we tested the hypothesis that there are PD-related dysfunctions
in the central olfactory functional network at the early stage of Parkinson's disease.
Figure 1. Significantly
weaker FC with bilateral POCs in the left substantia nigra (SN), temporal pole,
interior temporal gyrus, insular cortex, and posterior hippocampus and parahippocampal
gyrus of PDs (2-sample t-test, uncorrected, p < 0.005, extent threshold = 6
voxels)
Values
are
presented in mean ± SD. *, p <
0.05, MoCA,
Montreal Cognitive Assessment; UPDRS, Unified Parkinson’s Disease Rating Scale;
N/A, not applicable.