0595
View Abstract / View Presentation
One-year follow-up of functional lung MRI in children with cystic fibrosis
Corin Willers1, Lukas Maager1, Bettina S. Frauchiger1, Kathryn Ramsey1, Grzegorz Bauman2,3, Orso Pusterla2,3, Oliver Bieri2,3, and Philipp Latzin1
1Division of Pediatric Respiratory Medicine, Department of Pediatrics,, Inselspital, Bern University Hospital, University of Bern, Switzerland, Bern, Switzerland, 2Division of Radiological Physics, Department of Radiology, University of Basel Hospital Basel, Basel, Switzerland, Basel, Switzerland, 3Department of Biomedical Engineering, University of Basel, Basel, Switzerland, Basel, Switzerland
Changes in Matrix Penicil MRI at 1-year follow up are in a majority of cases in agreement with changes in lung function. In incongruent cases Matrix Pencil MRI helps to understand and interpret lung function.

Figure 4. Case examples with impeded correlation between Delta-VDP and Delta-LCI. (See red dots in figure 2 and 3)

A) At baseline a large ventilation defect, due to mucus plugging is visible (red arrow). At 14 months follow-up, the VDP has reduced, but LCI stayed stable. Baseline (delta) FEV1: -1.7 (+0.9), LCI: 9.6 (-0.2), VDP: 28.4% (-7.9).

B) At follow-up, an increased VDP is visible (red arrowhead). The LCI decreased (improved). Due to possibly more mucus plugging the LCI is “blind” to closed lung areas. Baseline (delta) FEV1, z-score: -0.1 (-0.7), LCI: 10.4 (-1.8), VDP: 20.4% (+5.6).

Figure 3. Arrow plot of baseline LCI (x-axis) and VDP (y-axis) to follow-up LCI and VDP. Redline marks the upper limit of normality. The arrow points from baseline to follow-up. Overall good agreement in the delta-VDP and delta-LCI is visible. Two outliers are marked as red dots and are shown in figure 4.

Note. – VDP: ventilation defect percentage; LCI: Lung clearance index