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CT-to-MR image synthesis: A generative adversarial network-based method for detecting hypoattenuating lesions in acute ischemic stroke
Na Hu1, Tianwei Zhang2, Yifan Wu3, Biqiu Tang1, Minlong Li1, Qiyong Gong1, Shi Gu2, and Su Lui1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Computer and Engineering, University of Electronic Science and Technology of China, Chengdu, China, 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States
With synthetic MRI compared to CT, sensitivity was improved by 116% in patient detection and 300% in lesion detection, and extra 75% of patients and 15% of lesions missed on CT were detected on synthetic MRI.
Figure 3. Example of patient detection using synthetic MRI (syn-MRI) versus CT in the testing set. Brain baseline CT (left) fails to show any definite hypoattenuating lesions, although the gray-white matter junction of the right insula is suspected. Synthetic MRI (middle) shows distinct hyperintensity in the territory of middle cerebral artery on the right, which is corresponding to the finding on the follow-up MRI (right).
Figure 1. Training and Testing of the generative adversarial network model.