Nan Wang1, Tianle Cao1,2, Fei Han3, Yibin Xie1, Xiaodong Zhong3, Sen Ma1, Xinheng Zhang1,2, Xiaoming Bi3, Mazen Noureddin4, Vibhas Deshpande3, Anthony G Christodoulou1, and Debiao Li1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, 4Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, 4Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States
A Multitasking multi-echo (MT-ME) technique was proposed for liver characterization, achieving 3D free-breathing acquisition and simultaneous quantification of T1, T1w, PDFF, and R2*. The quantitative parameters were repeatable and consistent with the references.
Figure 4: Representative T1, T1w, PDFF, and R2* maps from a 64-year-old patient with NAFLD. The mean T1, PDFF, and R2* of reference were 779 ms, 15.5%, 89 s-1, respectively, while the mean T1, T1w, PDFF, and R2* measured from MT-ME were 785 ms, 643 ms, 15.5%, and 85 s-1.
Figure 3: (A) Bland-Altman plots demonstrated good in vivo repeatability of the multiparametric mapping from MT-ME. Theoverall inter-scan differences for T1 and T1w were less than 3%, while the differences for PDFF and R2* were less than10%. (B) The regression analysis of T1, PDFF, and R2* measured with MT-ME and references showed good agreement on the 14 volunteers. The Rs was 0.990, 0.976, and 0.953, respectively.
