0647
Estimation of intra-axonal axial diffusivity by tensor-valued dMRI and powder-averaging
Markus Nilsson1, Samuel St-Jean1,2, Christian Beaulieu2, and Filip Szczepankiewicz1
1Clinical Sciences Lund, Lund University, Lund, Sweden, 2Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada
We demonstrate a new approach for estimation of the intra-axonal axial diffusivity based on b-tensor encoding and powder averaging which is well-posed and does not rely on assumptions.
Fig. 1. Intra-axonal axial diffusivity estimated using the proposed approach. Values were lowest in the anterior white matter (green), intermediate in the posterior white matter (red), and highest in the corticospinal tract (blue).
Fig. 2. Maximum-intensity projections of the intra-axonal axial diffusivity across multiple slices illustrating the elevated values of intra-axonal axial diffusivity found in the corticospinal tract and the brainstem.