0657
Detection of fine-scale functional networks in spinal cord and the effects of injury on intra- and inter-segmental networks
Anirban Sengupta1, Arabinda Mishra1, Feng Wang1, Li Min Chen1, and John C. Gore1
1Vanderbilt University Medical Center, Nashville, TN, United States
Robust BOLD fMRI fluctuations were detected at the bilateral intermediate region and gray-commissure region of spinal cord. Selective disruption of dorsal column white matter tract damages the inter-segmental connectivity more than the intra-segmental connectivity.
Figure 4. (A) Connectivity matrix at different time-points arranged such that the connectivities from same community are next to each other. Red boxes on the matrix highlight the communities formed using graph theory principles. (B) The resulting communities are shown in different colors overlaid on a grid matrix. The columns of grid matrix represent the seven ROI and the rows represent the five slices/segments. No IR component was observed from slice 2 and kept white in color. Note community structures change and hence their number and colors don’t match across time points.
Figure 3: (A) Connectivity matrix averaged over 14 runs of 5 monkeys at different time points with intra-slice and neighboring inter-slice connectivities highlighted in black triangles and black box respectively. Box-plot of (B) intra-slice connectivities and (C) neighboring inter-slice connectivities at different time points. Box-plots for intra-slice and neighboring inter-slice are computed from their corresponding significant connectivity measures. Significantly different box-plots (Wilcoxon non-parametric test) are denoted by * (p<0.05) and * * (p<0.01) . .