Ruiming Chen1, Sydney Nguyen2,3,4, Megan E. Murphy2,3,4, Kathleen M. Anthony2,3,4, Terry K. Morgan5, Philip Corrado1, Sean B. Fain1,6, Dinesh M. Shah7, Ronald R. Magness8, Thaddeus Golos2,3,4, Oliver Wieben1,6,9, and Kevin M. Johnson1,9
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, 3Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, 4Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 5Pathology, Oregon Health & Science University, Portland, OR, United States, 6Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 7Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 8Obstetrics and Gynecology, University of South Florida, Tampa, FL, United States, 9Radiology, University of Wisconsin - Madison, Madison, WI, United States
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, 3Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, 4Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 5Pathology, Oregon Health & Science University, Portland, OR, United States, 6Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 7Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 8Obstetrics and Gynecology, University of South Florida, Tampa, FL, United States, 9Radiology, University of Wisconsin - Madison, Madison, WI, United States
Results show regional heterogeneity in fractional blood volume and increase of maternal placental blood volume throughout gestation ages.
Figure 2. Representative FBV distribution for a control rhesus macaque. FBV ranges from 0 to 1, with 1 being 100% blood in certain placental regions. FBV exhibits regional heterogeneity, similar to heterogeneous perfusion [7].
Figure 3. Measurements of maternal placental blood volume (MPBV) and fractional blood volume (FBV) as a function of gestational age. MPBV shows constant increase throughout pregnancy; FBV exhibits a more heterogeneous trend, with higher relative change from first to second gestational age time point.