Sarah Rosemary Morris1,2,3, Irene M. Vavasour1,4, Anastasia Smolina5,6, Erin MacMillan4,7, Guillaume Gilbert7, Michelle Lam2,4, Piotr Kozlowski1,2,4,8, Carl Michal2, Alan Manning2, Alex L. MacKay1,2,4, and Cornelia Laule1,2,4,8,9
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4UBC MRI Research Centre, Vancouver, BC, Canada, 5Physics & Astronomy, McMaster University, Hamilton, ON, Canada, 6Hospital for Sick Children, Toronto, ON, Canada, 7MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 8International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 9Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4UBC MRI Research Centre, Vancouver, BC, Canada, 5Physics & Astronomy, McMaster University, Hamilton, ON, Canada, 6Hospital for Sick Children, Toronto, ON, Canada, 7MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 8International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 9Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
Inhomogeneous magnetization transfer and myelin water imaging metrics (ihMTR and MWF) from white matter of healthy adults were compared. We found a moderately strong correlation between these two metrics and a good reproducibility for ihMTR.
Figure 2: Example magnetization transfer ratio (MTR), inhomogeneous MTR (ihMTR) and myelin water fraction (MWF) maps from five of the participants. ihMTR and MWF show more variation in white matter than MTR.
Figure 3: Pearson correlations between MTR and MWF and ihMTR and MWF. (ACR=Anterior corona radiata, AIC=Anterior limb of internal capsule, BOD=Body of corpus callosum, CEP=Cerebral peduncle, CIN=Cingulum, EXC=External capsule, GEN=Genu, PCR=Posterior corona radiata, PIC=Posterior limb of internal capsule, PTR=Posterior thalamic radiation, RIC=Retrolenticular part of internal capsule, SAS=Sagittal stratum, SCR=Superior corona radiata, SLF=Superior longitudinal fasciculus, SPL=Splenium)
