Di Wu1 and Shun Zhang1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
In ischemic stroke, the OEF of the infarcted
area descends continuously from acute to chronic phase. Meanwhile, there exists
tissue that is likely to be penumbra in the acute diffusion lesion, of which
the OEF shows an increasing trend with time, suggesting timely reperfusion in this
region.
Figure 2. OEF of
the infarcted area defined on DWI and contralateral mirror area and their
quotient (rOEF) in four ischemic stroke phases. (a) OEF significantly reduced
compared with the contralateral mirror area in all four stroke phases
(two-tailed paired-t test, p < 0.05 for all). Besides, OEF showed a trend of
decrease from acute to chronic phase and was statistically significant (ANOVA, p
= 0.022). (b) rOEF showed the same decreasing tendency with OEF (ANOVA, p = 0.024).
The center line is the mean and the other two lines are standard deviation; *p
< 0.05, **p < 0.01, ***p < 0.001.
Figure 3. OEF and
rOEF of initial diffusion lesion, mismatched area and final infarct among different
phases in the 8 patients whose final infarct volume was smaller than initial
diffusion lesion according to longitudinal MR scans. OEF (a) and rOEF (b) of
the final infarct showed a trend of decrease with time, while those of the initial
diffusion lesion and the mismatched area increased. Note that only increasing
trend of OEF of the mismatched area reached statistical significance (repeated
measures ANOVA, p = 0.022).