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Prediction of the Treatment Efficacy of Patients with Subacute Cerebral Infarction using the Heterogeneity of APT-weighted Signals

Yuhan Jiang¹, Peipei Chang¹, Yingqiu Liuyang¹, Bingbing Gao¹, Yiwei Che¹, Renwang Pu¹, Qingwei Song¹, Ailian Liu¹, Zhiwei Shen², Jiazheng Wang², and Yanwei Miao¹
¹the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Philips Healthcare, Beijing, China

In this study, we investigated the change of APTw_max-min signals in the ischemic regions in the subacute infarction, and elucidated the relationship with ∆NIHSS score. Results showed the APTw_max-min signal was inversely correlated with ∆NIHSS score.

Fig 1 A 56-year-old female with a subacute infarction 78 hours after the onset. a: DWI shows the hyperintense infarct area near the right lateral ventricle. b: The infarct area was low perfusion on the CBF image with 1.5 PLD. c: The infarct area was slightly hypointense on the APTw image. d: DWI-CBF fusion map shows the IC and IP. The ROI of the IC (white line) and the IP (orange line) is indicated. e: DWI-APTw fusion map. The ROI was copied from the DWI-CBF fusion map.

Fig 3 Association between APTw_max-min signal in and ∆NIHSS score in IC and IP. (a) The APTw_max-min within IC was inversely correlated with the ∆NIHSS score (R2 = 0.184, P = 0.041). (b) The APTw_max-min within IP showed negative correlation with ∆NIHSS scores (R2 = 0.255, P = 0.014).