Lars Mueller1, Maryam Afzali1, Malwina molendowska1, Chantal M.W. Tax1,2, Fabrizio Fasano3,4, Suryanarayana Umesh Rudrapatna1, and Derek K. Jones1,5
1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 3Siemens Healthcare Ltd, Camberly, United Kingdom, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Mary McKillop Institute for Health Research, Faculty of Health Sciences, Australian Catholic University, Melbourne, Melbourne, Australia
1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 3Siemens Healthcare Ltd, Camberly, United Kingdom, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Mary McKillop Institute for Health Research, Faculty of Health Sciences, Australian Catholic University, Melbourne, Melbourne, Australia
This work demonstrates the feasibility of estimating microstructure parameters from a free gradient waveform diffusion sequence with spiral readouts in a biomimetic phantom.
Parameters
estimated from LTE and STE spiral images. The mean diffusivity (MD) is higher
in the free water than in the vials with microstructure. The microscopic
isotropic diffusion coefficent (Diso) is lower than MD in the microstructure. The
fractional anisotropy (FA) is higher than the microscopic FA ($$$\mu$$$FA). The
estimates of $$$\mu$$$FA in the free water is relatively high which is due to the fact
there was only noise left for the higher b-value.
Sequence diagram for the free gradient waveform diffusion
sequence with spiral readout.
