0917
RF-encoding for improved multi-voxel separation in MR spectroscopy
Adam Berrington1, Penny Gowland1, and Richard Bowtell1
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
Phase and amplitude signal modulation was shown to improve the g-factor of reconstruction for 5 voxels in simulation. Phantom spectra from two-voxels were acquired over M=1…5 encoding steps with 30° phase increments and were of higher SNR than reconstructing using coil-encoding alone.
Fig.1: RF-encoding simulated with unique spectral peaks assigned to 5 voxel ‘locations’ (coloured regions). A) Encoding scheme applied to each voxel at each encoding step, $$$m=1…5$$$. Amplitude was weighted randomly between 0.8 and 1 and phase modulated between 0 and 180$$$^{\circ}$$$. B) Receive sensitivities (shown for two coils), which are combined with (A) to generate weighted signals at each channel for each encoding step, $$$m$$$. Signals are concatenated over M=5 steps. C) Inversion of the system matrix, $$$\bf S$$$, reveals reconstructed signals from each voxel.
Fig. 4: Data acquired from two voxels (voxel 1=blue; voxel 2=orange) in a phantom (A) using proposed RF-encoded technique with an increasing number of encoding steps, M. (B) Combined signal (not unfolded) from all receive coils shows shot-to-shot variation in phase from (0°,30°,60°,90°,120°) modulation on voxel 2 using the dual-band pulses. (C) Reconstructed data using RF-encoding (steps M=2-5) are shown below coil-encoding only (M=1). The spectral SNR and effective g-factor values are stated next to each encoding.