Xiuhong Guan1, Jiali Cai2, Xiangyu Xiong1, Hong Liu2, Shihui Huang2, Sheng Wang2, Chuanqi Sun1, Yi Sun3, Tianjing Zhang4, Guoxi Xie1, and Zhiyong Wang2
1Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, 2School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, China, 3Siemens Healthineers, Shanghai, China, 4Philips Healthcare, Guangzhou, China
1Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China, 2School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, China, 3Siemens Healthineers, Shanghai, China, 4Philips Healthcare, Guangzhou, China
This
study reports a kind of functional nanocomposite, superparamagnetic iron oxide
nanocrystals (SPIO@NC), exhibiting NIR-II and MR dual-modal imaging guided chem-phototherapy
and anti-tumor immunity against triple-negative breast cancer.
Schematic
illustration of experimental flow. Schematic illustration of SPIO@NC
synthesis and experiments in mice in
vitro and in vivo.
Fig.
4 (A)(B)Representative flow cytometric analysis displaying the
absolute percentage of (A)
M1
(MHC-II+) and M2 (CD206+) macrophages in CD45+CD11b+ tumor cells,
and (B) CD8+ T cells and
CD4+ T cells in CD45+CD3+
tumor cells from mice with different
treatments at 7 days. (n = 5). (C) Representative immunofluorescence
imaging of Treg cells (CD4+FoxP3+)
in tumor from mice received various
treatments on 7th days. Scale bar, 30μm. (D)(E) Real
pictures of tumors(D) and (E) after dissection from mice received different
treatments.