Nan Wang1, Jingjuan Qiao2, Zhijun Wang3, Pei Han1,4, Hsu-Lei Lee1, Sen Ma1, Hui Han1, Zhaoyang Fan1, Anthony G. Christodoulou1, Ekihiro Seki3, Stephen Pandol5, Debiao Li1, Jenny Yang2, and Yibin Xie1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Chemistry Department, Georgia State University, Atlanta, GA, United States, 3Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 5Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Chemistry Department, Georgia State University, Atlanta, GA, United States, 3Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 5Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, United States
A Multitasking technique was proposed for mouse abdominal imaging at 3T, achieving 3D motion-resolved acquisition and simultaneous T1 T2 mapping within 10 minutes. It produced better images with vastly reduced scan time on a murine model with liver metastasis of colorectal cancer.
Figure 4: T1-T2-weighted images and T1 T2 maps from conventional methods and from Multitasking acquired on an HFD mouse at week 2 with ProCA.collagen1 injection. Multitasking consistently showed improved image quality. The tumor were labeled by red dashed boundary on T2W TSE. Tumor showed higher T1 and T2 values compared to normal liver parenchymal, which was consistent with conventional methods and Multitasking. Some breathing artifacts on conventional images were labeled by white arrows
Figure 3: T1-T2-weighted images and T1 T2 maps from conventional methods and from Multitasking acquired on an LFD mouse at week 1 with Eovist injection. In each imaging session, conventional image series took about 45 to 50 minutes in total, while Multitasking can generate T1-T2-weighted images and T1 T2 maps in one single 10-min scan. Moreover, Multitasking produced improved image quality in both weighted images and quantitative maps. Some breathing artifacts on conventional images were labeled by white arrows
