Qi Qi1,2,3, Matthew Fox1,4, Robert Bartha2,5,6, Miranda Bellyou5, Lise Desjardins7, Lisa Hoffman1,2,8, Alex Li5, Andrew McClennan1,2, Ting Yim Lee1,2,3,5,6, and Jonathan D Thiessen1,2,3,6
1Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada, 3Molecular Imaging, Western University, London, ON, Canada, 4Physics and Astronomy, Western University, London, ON, Canada, 5Robart Research Institute, London, ON, Canada, 6Medical Imaging, Western University, London, ON, Canada, 7Lawson Health Research Institute, London, ON, Canada, 8Anatomy and Cell Biology, Western University, London, ON, Canada
1Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada, 3Molecular Imaging, Western University, London, ON, Canada, 4Physics and Astronomy, Western University, London, ON, Canada, 5Robart Research Institute, London, ON, Canada, 6Medical Imaging, Western University, London, ON, Canada, 7Lawson Health Research Institute, London, ON, Canada, 8Anatomy and Cell Biology, Western University, London, ON, Canada
This study demonstrates the capability of
simultaneous measurements of pHi and pHe using CEST MRI,
a more complete picture of the tumour pH environment, and explores the
intrinsic relationship between tumour glycolysis and its pH environment.
Figure 2: Illustrative examples
of baseline (a) and post-injection (b) AACID maps; baseline (c)
and post-injection (d) acidoCEST maps. All maps are overlaid on top
of the corresponding T2-weighted MRI. The tumour region is delineated with the
red-dotted line, and the peri-tumour region is contoured with the light-blue-dotted
line using the T2-weighted MRI.
Figure 1: An illustrative
example of the FDG-PET image of the last frame (SUV, a), time-activity
curve from the tumour region (b) delineated with red-dotted line, and
the arterial input function (AIF) from the left ventricle of the heart delineated
with white-dotted line (c, d). The axial SUV map is overlaid on top of
the corresponding T2-weighted MRI.