Giacomo Annio1,2, Ahmed Hamimi3, Khaled Z. Abd-Elmoniem 3, Theo Heller3, Elliot Levy 3, David E. Kleiner4, Ohad Etzion5, Rabab Ali6, Ralph Sinkus1,2, and Ahmed M. Gharib3
1LVTS, INSERM U1148, Paris, France, 2Department of Biomedical Engineering, King's College London, London, United Kingdom, 3Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, 4Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, 5Department of Gastroenterology and Liver Diseases, Ben-Gurion University of the Negev, Be'er Sheva, Israel, 6Department of Internal Medicine, Duke University, Durham, NC, United States
1LVTS, INSERM U1148, Paris, France, 2Department of Biomedical Engineering, King's College London, London, United Kingdom, 3Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States, 4Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States, 5Department of Gastroenterology and Liver Diseases, Ben-Gurion University of the Negev, Be'er Sheva, Israel, 6Department of Internal Medicine, Duke University, Durham, NC, United States
The gold standard for the assessment of liver fibrosis and
inflammation are invasive measurements of portal venous pressure (PVP). In this
work we show that liver stiffness quantified via 3DMRE is a strong independent
predictor of PVP compared to invasive biopsy.
Figure 2: Correlation curves of Gd and Ishak fibrosis score vs DPVP, with the relative linear fit, the R-squared value and the respective Spearman's coefficient of rank correlation (rho).
Figure 1: Anatomy, y-component of the curl of the displacement
vector, shear stiffness and viscosity, for
two selected patients with low (Pat A) and high DPVP (Pat B) (Pat A: DPVP 3mmHg
and fibrosis score 1, Pat B: DPVP 28 mmHg and fibrosis score 6).
