Ryan McNaughton1, Hernan Jara1,2, Chris Pieper2, Julie Rollins3, Osamu Sakai2, Laurie Douglass2, Rebecca Fry3, Karl Kuban2, and T. Michael O'Shea3
1Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States
1Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States
MS-qMRI of the EP brain at
adolescence comprehensively quantifies the dysmaturation states, from white
matter structure to CSF composition. Maps of T1, T2, PD, and spatial entropy generated
for 341 EP born individuals, exhibited linear relationships of T1 and PD with
SE, and T2 with CSF volume.
Example
MS-qMRI maps of (A) T1, (B) T2, (C) PD, and (D) Spatial Entropy for a
15-year-old female.
Scatterplots
of the mean T1 versus spatial entropy of the white matter within the
intracranial matter. The solid lines represent linear regression of females
(circle) and males (triangle). Distribution plots of the variables are provided
to highlight gender related differences.