Nareen Anwar1, Wesley J Tucker2, Nancy Puzziferri3, Jake Samuel2, Vlad G Zaha3, Ildiko Lingvay3, Jaime Almandoz3, Jing Wang2, Edward A Gonzales2, Matthew Brothers2, Michael Douglas Nelson2, and Binu P Thomas2,3
1The University of Texas at Dallas, Richardson, TX, United States, 2The University of Texas at Arlington, Arlington, TX, United States, 3University of Texas Southwestern Medical Center, Dallas, TX, United States
1The University of Texas at Dallas, Richardson, TX, United States, 2The University of Texas at Arlington, Arlington, TX, United States, 3University of Texas Southwestern Medical Center, Dallas, TX, United States
The mechanisms that drive improvements in neurocognitive function after bariatric surgery are unknown. In this study, magnetic resonance imaging is utilized to assess changes in cerebral metabolic rate of oxygen (CMRO2) levels in bariatric surgery candidates before and after their surgery.
A comparison of (a) BMI and (b) cognitive function within bariatric
surgery candidates before (Bar-pre), 2 weeks after (Bar-post 2wk), and 14 weeks
after surgery (Bar-post 14wk). Compared to pre-surgery BMI, Bariatric surgery
candidates have a significantly reduced BMI 2 weeks after surgery (p = 0.001)
and 14 weeks after surgery (p = 0.0001). Cognitive function increases and is
significantly greater 2 weeks post-surgery (p = 0.026) and 14 weeks
post-surgery (p = 0.003) when compared to pre-surgery.
A comparison of CMRO2 among bariatric surgery candidates
before, 2 weeks after (Bar-post 2wk), and 14 weeks after surgery (Bar-post
14wk), young healthy controls (YHC) and age matched healthy controls (AM HC).
Before bariatric surgery, patients have a significantly higher CMRO2
than AM HC (p = 0.02), as well as 2 weeks post-surgery (p = 0.003).