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Graph-based global reasoning of DWI tractography connectome allows reproducible prediction of language impairment in pediatric epilepsy
Jeong-Won Jeong1, Soumyanil Banerjee2, Min-Hee Lee1, Nolan O'Hara3, Csaba Juhasz1, Eishi Asano1, and Ming Dong2
1Pediatrics, Wayne State University, Detroit, MI, United States, 2Computer Science, Wayne State University, Detroit, MI, United States, 3Translational Neuroscience Program, Wayne State University, Detroit, MI, United States
Global reasoning and aggregation of DWI connectome features improved the prediction of language impairment in children with focal epilepsy without relying on a specific DWI connectome node configuration when compared to other deep learning methods.
Figure 3. Examples of activation maps highlighting the important Ωi for prediction of expressive and receptive language score. Each 3D visualization shows the nodes of Ωi and their contributions (i.e., Z scores of attenuation weights) to increase the prediction accuracy, quantified by the thickness of an individual tube. Thicker tubes indicate that a node is more predictive of observed language scores. Relatively small attention weights (i.e., Z-scores less than 2.5 standard deviations of each map) were omitted for clarity.
Figure 1. The architecture diagram of the proposed CNN+GCN model, which takes the connectome matrix S as input, to predict an output score t. Here, “**” indicates 2D convolution, and “*” indicates 1D convolution. In the final layer, a linear unit is used for language score regression.