Xinyue Wan1, Xiaorui Su1, Simin Zhang1, Qiyong Gong1, and Qiang Yue2
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Radiology, West China Hospital of Sichuan University, Chengdu, China
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Radiology, West China Hospital of Sichuan University, Chengdu, China
To explore metabolic alterations of DLPFC in GTCS and the effect of AEDs on metabolites concentration.
Fig.2 Metabolic difference among each group in the left (a) and right (b) DLPFC. *p < 0.05. Abbreviations: DLPFC, dorsolateral prefrontal cortex; HC, healthy control; Ins, Myoinositol; NAA, N-acetyl aspartate; Cho, choline; Cr, creatine; Glx = Glu + Gln (Glu, glutamate, Gln, glutamine).
Table 2. Metabolite concentrations (mmol/kg wet weight) of DLPFC in pre-/post-treatment GTCS patients and HC. Abbreviations: Ins, Myoinositol; NAA, N-acetyl aspartate; Cho, choline; Cr, creatine; Glx = Glu + Gln (Glu, glutamate, Gln, glutamine). a p < 0.05, compared with metabolite concentrations on the right DLPFC; b p < 0.05, compared with metabolite concentrations on the same side DLPFC of HC; c p < 0.05, compared with metabolite concentrations on the same side DLPFC of HC; d p < 0.05, compared with metabolite concentrations on the same side DLPFC of pre-treatment patients.