Lijing Xin1,2, Philippe Reymond3, José Boto3, Serge Vulliemoz4, Francois Lazeyras 5, and Maria Isabel Vargas3
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Division of Neuroradiology, Diagnostic Department of Geneva University Hospitals and University of Geneva, Geneva, Switzerland, 4Division of Neurology, Neurosciences Department of Geneva University Hospitals and University of Geneva, Geneva, Switzerland, 5Center for Biomedical Imaging of Geneva and University of Geneva, Geneva, Switzerland
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Division of Neuroradiology, Diagnostic Department of Geneva University Hospitals and University of Geneva, Geneva, Switzerland, 4Division of Neurology, Neurosciences Department of Geneva University Hospitals and University of Geneva, Geneva, Switzerland, 5Center for Biomedical Imaging of Geneva and University of Geneva, Geneva, Switzerland
This study evaluated the tissue neurochemical by 1H
MRS in patient with epilepsy at 7T. Significant changes in macromolecule, N-acetyl
aspartate, total choline, glycine+myo-inositol, and a reduction trend of
glutamate were found in lesions of focal cortical dysplasia.
Figure 1. Neurochemical changes between lesion and
contralateral side in epilepsy patients with focal cortical dysplasia and non
MRI detectable lesion (* p< 0.05, + p<0.06).
Table 1.
Demographic data for patients (n=13)
including clinical presentation, seizure frequency, MR diagnosis and post-operative
clinical outcome.