Salem Alkhateeb1, Tales Santini2, Regina Leckie2, nadim farhat2, Peter J Gianaros2, Anna L Marsland2, Stephen B Manuck2, and Tamer S Ibrahim2
1Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 2University of Pittsburgh, Pittsburgh, PA, United States
1Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 2University of Pittsburgh, Pittsburgh, PA, United States
As hippocampal volume has been extensively utilized as a diagnosing tool to confirm diagnosis of many neurological disorders, this study aims to employ the high resolution 7T data to segment the hippocampal subfields then correlate their volumes with the age of healthy adults’ population. The region encompassing the subregions left DG, CA2, and CA3 showed significant correlation with age, with a volume variation of approximately -1% per year. Other regions presented a trend towards reductions that did turn into significant. Future work will investigate if differences in the hippocampus subfields are correlated with cognitive performance in this population.
Figure (3): In a) The final product of the hippocampus segmentation pipeline, each color represents a specific subfield. In b) Example of manual correction of a lesion that is labeled as DG.
Figure (2) First two stages of Image preparations for registration and segmentation. Top row shows the MPRAGE T1 weighted images, bottom row shows the TSE T2 weighted images