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Investigating the extent of difference in single tensor and beyond single tensor diffusion MRI-derived voxelwise measures
Virendra R Mishra1, Karthik Sreenivasan1, Dietmar Cordes1, Aaron Ritter1, and Charles Bernick2
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Washington - Seattle, Seattle, WA, United States
Our findings suggest that white-matter disorganization is prevalent due to repeated head impacts, although, the spatial extent and location of these differences are heavily dependent on the diffusion MRI models utilized in the study.
Figure 3: Top: Regions with significantly lower FWFA in boxers as compared to HC are overlaid on MNI template. Middle: Regions with significantly lower FWRD in HC as compared to boxers are overlaid on MNI template. Bottom: Regions with significantly lower FWMD in HC as compared to boxers are overlaid on MNI template. Average values in the cluster are extracted for each participant and shown as a boxplot. Average values in each significant cluster for boxers and HC are shown as blue and red dots, respectively.
Figure 1: Top: Regions with significantly lower ST dMRI-derived FA in boxers as compared to HC are overlaid on MNI template. Middle: Regions with significantly lower ST dMRI-derived RD in HC as compared to boxers are overlaid on MNI template. Bottom: Regions with significantly lower ST dMRI-derived MD in HC as compared to boxers are overlaid on MNI template. Average values in each cluster are extracted for each participant and shown as a boxplot. Average values in the significant cluster for boxers and HC are shown as blue and red dots, respectively.