Binu P. Thomas1,2, Takashi Tarumi3,4, Ciwen Wang3, David C. Zhu5, Tsubasa Tomoto4, C. Munro Cullum3,6,7, Marisara Dieppa3, Ramon Diaz-Arrastia8, Kathleen Bell9, Christopher Madden6, Rong Zhang3,4, and Kan Ding3
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States, 3Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States, 5Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, United States, 6Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 8Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 9Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, United States
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States, 3Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States, 5Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, United States, 6Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 8Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 9Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, United States
CBF deficits in the hippocampus, thalamus and other subcortical structures were observed in patients with chronic TBI compared to controls. CBF in the hippocampus and anterior cingulate were negatively associated with TBI-related symptoms of anxiety, fatigue, depression and sleep-issues.
Figure
1. Voxel-wise comparison (T-score map) of CBF in the group with TBI to the NC
group. The colored voxels indicate regions with statistically significant CBF
deficit in the group with TBI compared to the NC group (p=0.005, uncorrected,
minimum cluster size (k) = 50 voxels). Cross sectional view through the CBF
deficit cluster in: (a) the Thalamus and (b) the left Hippocampus. Colored
voxels are overlaid onto a group averaged CBF map from all participants in both
TBI and NC groups. CBF: cerebral blood flow.
Figure
3. Negative correlation between hippocampus CBF (a – d) and TBI-related
symptoms of (a) Fatigue (p=0.002), (b) Anxiety (p=0.01), (c) Depression
(p=0.01), and (d) Sleep Impairment (p=0.008) and negative correlation between
rostral anterior cingulate cortex CBF (e – h) and TBI-related symptoms of (e)
Fatigue (p=0.0003), (f) Anxiety (p=0.045), (g) Sleep Disturbance (p=0.01), and
(h) Sleep Impairment (p=0.01). Significant correlations are denoted as: *
p<0.05; ** p<0.005; *** p<0.0005