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Blast-Induced Neurotrauma Results in Spatially Distinct Gray Matter Alteration alongside Hormonal Alteration
Sarah Hellewell1 and Ibolja Cernak2
1Curtin University, Nedlands, Australia, 2Mercer University, Macon, GA, United States
Widespread, symmetric loci of reduced gray matter volume blast-induced neurotrauma (BINT) were found in active military & veterans, alongside significant increases in testosterone, cortisol and the testosterone/cortisol ratio.
Figure 1. Significant clusters of gray matter alteration in BINT participants vs. first responders. Whole-brain voxel based morphometry was performed to determine volume differences between BINT and occupational stress groups. Color map indicates scale for t-statistic.
Figure 2. Testosterone, cortisol and T/C ratio in BINT vs. chronic stress groups. Testosterone and cortisol are presented as Z scores of hormone concentrations, while the T/C ratio is calculated from raw values in pg/mL.