Blast-Induced Neurotrauma Results in Spatially Distinct Gray Matter Alteration alongside Hormonal Alteration
Sarah Hellewell1 and Ibolja Cernak2
1Curtin University, Nedlands, Australia, 2Mercer University, Macon, GA, United States
Widespread, symmetric
loci of reduced gray matter volume blast-induced neurotrauma
(BINT) were found in active military & veterans, alongside
significant increases in testosterone, cortisol and the testosterone/cortisol
ratio.
Figure 1. Significant clusters of gray
matter alteration in BINT participants vs. first responders. Whole-brain voxel based morphometry was performed
to determine volume differences between BINT and occupational stress groups. Color
map indicates scale for t-statistic.
Figure 2.
Testosterone, cortisol and T/C ratio in BINT vs. chronic stress groups. Testosterone
and cortisol are presented as Z scores of hormone concentrations, while the T/C
ratio is calculated from raw values in pg/mL.