Study of brain abnormalities in Myalgic Encephalomyelitis /Chronic Fatigue Syndrome patients using diffusion tensor imaging
Kiran Thapaliya1,2, Donald Staines1, Sonya Marshall-Gradisnik1, and Leighton Barnden1
1Griffith University, Gold Coast, Australia, 2Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia
Brain stem abnormalities detected by
diffusion tensor imaging could be the potential cause of Myalgic
Encephalomyelitis/ Chronic fatigue syndrome.
We also found significant decrease of eigenvalues and mean diffusivity (MD) in brain stem of ME/CFS patients compared to healthy controls
Fig. 1 demonstrates the results of the
voxel-based analysis of λ1, λ2, MD, and RD. In the ME/CFS patients, there were
significant decreases in λ1, λ2, MD, and RD in the pons of the brain stem.
Fig. 2 demonstrates the results of the
voxel-based analysis of λ3 and RD. In the ME/CFS patients, there were
significant increases in λ3 and RD in the medulla (white arrow) and cuneus
(black arrow) region.