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Study of brain abnormalities in Myalgic Encephalomyelitis /Chronic Fatigue Syndrome patients using diffusion tensor imaging
Kiran Thapaliya1,2, Donald Staines1, Sonya Marshall-Gradisnik1, and Leighton Barnden1
1Griffith University, Gold Coast, Australia, 2Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia

Brain stem abnormalities detected by diffusion tensor imaging could be the potential cause of Myalgic Encephalomyelitis/ Chronic fatigue syndrome.

We also found significant decrease of eigenvalues and mean diffusivity (MD) in brain stem of ME/CFS patients compared to healthy controls

Fig. 1 demonstrates the results of the voxel-based analysis of λ1, λ2, MD, and RD. In the ME/CFS patients, there were significant decreases in λ1, λ2, MD, and RD in the pons of the brain stem.
Fig. 2 demonstrates the results of the voxel-based analysis of λ3 and RD. In the ME/CFS patients, there were significant increases in λ3 and RD in the medulla (white arrow) and cuneus (black arrow) region.