Lin Chen1,2 and Jiadi Xu1,2
1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States
1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States
We demonstrated that creatine CEST is a highly pH-sensitive method at high field.
Figure 2. Representative Z-spectra for the GuanCEST experiments (a) pre
and (b) post-CO2 inhalation for the cortex region. The PCr peak is
observable and is indicated. Representative Z-spectrum of amideCEST experiment
(c) pre and (d) post-CO2 inhalation and CrCEST experiment (e) pre
and (f) post-CO2 inhalation for the cortex region. Solid lines are
the fitted background using the PLOF method. (g) Scatter plots showing the CEST
contrast difference for CrCEST, amideCEST and GuanCEST experiments obtained by
PLOF (n= 5) and the corresponding contrast changes (h).
Figure 1: (a) The typical
Z-spectra of egg white that titrated to 6.0, 6.5, 7 and 7.5 pH. The spectrum
was recorded using CW-CEST with 1μT and 3s
saturation at 37°C by an air heater. The CEST peaks from amide, amine,
guanidinium, amideNOE are indicated. The simulated DS spectrum for egg white
with pH 7.5 is also plotted.