Xiaohan Zhou1,2, Yi Hou3, Wentao Liu1, and Dong Han1,2
1National Centre for Nanoscience and Technology, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Beijing University Of Chemical Technology, Beijing, China
1National Centre for Nanoscience and Technology, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Beijing University Of Chemical Technology, Beijing, China
The novel agent PAA-Gd can display its high efficiency to visualize the stream in radiology and pathology study as a versatile enhancer.
Fig1. (A) The
synthetic scheme of zwitterionic MCP contrast agent PAA-Gd. (B) Viability
of HUVE cells treated by PAA-Gd and
Gd-DTPA. (C) Signal intensity map of T1 weighted MR images (TE= 10
ms, TR= 300 ms) of aqueous solution of PAA-Gd in 200 μL Eppendorf tubes
according to different Gd3+ concentration
from 0 to 1mM. (D) Linear regression fitting curve (solid line) of calculated
R1 value (‘■’ points) was performed.
Fig2. The
image obtained immediately (A) and 12 minutes (B) after intravenous injection of PAA-Gd. DCE images of
pre-injection (C), post-injection (D) and the final status of mouse after 30
minutes (E) on the kidney plane. A long distance transportation trace is
depicted and emphasized with white arrow in (F) on centric section.