Martina Vermathen1, Hendrik von Tengg-Kobligk2,3, Martin Nils Hungerbühler2,3, Christoph Kempf2,3, Peter Vermathen2,3, and Nico Ruprecht2,3
1Department of Chemistry and Biochemistry, University Bern, Bern, Switzerland, 2University Institute of Diagnostic, Interventional and Pediatric Radiology, University Bern, Bern, Switzerland, 3Department of BioMedical Research, University Bern, Bern, Switzerland
1Department of Chemistry and Biochemistry, University Bern, Bern, Switzerland, 2University Institute of Diagnostic, Interventional and Pediatric Radiology, University Bern, Bern, Switzerland, 3Department of BioMedical Research, University Bern, Bern, Switzerland
More than 40 metabolites were identified in lung
cancer cells and in induced and de-induced cisplatin (cisPt) resistant cells.
CisPt-resistant cells demonstrated metabolic adaptations that were maintained
in de-induced counterparts.
Figure 4:
A) oPLS scores plot (LV1 – LV2) using the resistance as scaled prior knowledge (y-table).
B) Description of the PLS model showing the measured compared to the predicted resistance values.
Figure 3:
PCA scores plot (PC1 – PC2) of all samples using the color and form coding introduced in Fig.1.
