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Merging T1 weighted images with QSM provides a unique contrast for brain tissue segmentation in humans and non-human primates
Rakshit Dadarwal1,2 and Susann Boretius1,2
1Functional Imaging Laboratory, German Primate Center, Göttingen, Germany, 2Georg August Universität Göttingen, Göttingen, Germany
We have proposed a method to combine T1w and QSM contrasts that significantly improves the quality of subcortical nuclei classification while retaining the excellent white matter delineation of T1w.
Figure 1. The juxtaposition of a human subject’s T1–QSM fusion image (TQ-SILiCON map) in comparison with the respective T1 weighted image (A, left) and QSM (B, left). TQ-SILiCON maps were generated with the weights of 0.318 and -0.790 for T1w and QSM respectively. 1 – thalamus, 2 – external globus pallidus, 3 – internal globus pallidus, 4 –substantia nigra, 5 – red nucleus, 6 – white matter, 7 – internal capsule, and 8 – pulvinar nucleus.
Figure 2. Illustration of a macaque’s T1-QSM fusion image (TQ-SILiCON map) in comparison with the respective T1 weighted image (A, left) and QSM (B, left). The emphasized areas on the TQ-SILiCON map are parts of the subcortical gray matter nuclei: 1 – thalamus, 2 – external globus pallidus, 3 – internal globus pallidus, 4 – substantia nigra, 5 – red nucleus, and 6 – white matter.