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Altered structural connectivity and impairment of brain network-cognition relationship in obstructive sleep apnea (OSA)
Tasfiya Islam1, Mengting Liu1, Dae Lim Koo2, Ryan Cabeen1, Eunyeon Joo3, and Hosung Kim1
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea, Republic of, 33Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Korea, Republic of
OSA patients were found to have globally less efficient brain network. In OSA, the higher modularity linked with network segregation and less efficient network may further lead to the failure in coordinating cognitive resources and the impaired visual memory function.
Figure 2: Network based statistics (NBS) under the contrast [-1, 1] for OSA and healthy control group connectivity comparison.
Figure 3: Scatter plot of significant effects found in data collected from behavioral versus brain measure comparison for both healthy and OSA subjects under threshold value of 0.35.