Jie Liu1, Hui Liu2, Qi Liu2, Jian Xu2, Hairong Zheng1, and Yin Wu1
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2United Imaging Healthcare America, Houston, TX, United States
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2United Imaging Healthcare America, Houston, TX, United States
We designed a Cramer-Rao bound based metric, and demonstrated its ability in evaluating the performance of acquisition strategies of CEST-MRF imaging in pH quantification.
Figure 3. (a-c) Values of CRB-, DP-, ED-based indexes with
varied acquisition number of 2-30; (d) RMSE of pH in MC simulation study using
both DP- and ED-based matching methods; RMSE of (e) log(kex) and (f)
respective pH values of the phantoms; the CEST-MRF measured pH maps in the
phantom study using both (g-i) DP- and (j-l) ED-based matching methods for representative
acquisition numbers of (g, j) 6, (h, k) 18 and (i, l) 30.
Figure 1. (a-c) Alterations of CRB-,
DP-, ED-based metrics with exchange
rates; RMSE of pH quantification
in MC simulation study using both DP- and ED-based matching methods under noise
levels of (d )20, (e) 40 and (f) 55 dB; RMSE of (g) log(kex) and (h)
pH of the phantom; (i) correlation of the measured and the titrated pH values
for vials with the same concentration of 60mM.