Altered brain networks dynamics in first-episode drug-free schizophrenia
Wanfang You1, Lekai Luo1, Qian Li1, Yuxia Wang1, Qiyong Gong1, and Fei Li1
1Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, chengdu, China
Patients with schizophrenia was mainly manifested as prolonged dwell time in a
state characterized by sparsely connected FCs and increased temporal
variability of centrality in the visual network, which may help to better
interpret mechanisms underlying hallucination in
schizophrenia.
Figure 4. Results map of the independent components (ICs)
showed between-group differences in eigenvector centrality (EC). Patients with
schizophrenia showed increased temporal dynamics of EC in IC50 (P=0.0286) and IC51 (P=0.0286) involved in visual networks compared with controls.
Figure 2. Compared with the controls, patients with
schizophrenia shown altered state transition vectors of mean dwell time and
fractional time in states 1 and 3 (P<0.05, FDR corrected).