Kun Qin1, Nanfang Pan1, Ziyu Zhu1, Feifei Zhang1, Jing Yang1, Xueling Suo1, and Qiyong Gong1
1West China Hospital of Sichuan University, Chengdu, China
1West China Hospital of Sichuan University, Chengdu, China
Abnormal activation in the precuneus, insula and parietal cortex was related to genetic vulnerability in high-risk relatives of patients with mood disorders. The most affected behavioral domian associated with the funtional abnormalities in high-risk relatives was emotion.
Figure 1. Transdiagnostic clusters with abnormal functional activation in high-risk relatives of patients with mood disorders. (A) Transdiagnostic meta-analysis identified three clusters of hyper- or hypo-activation in the insula, IPL and precuneus. Hyper-activated cluster was drawn in yellow or red, while hypo-activated clusters were drawn in green or blue. (B) Correlation coefficients of each behavioral domain with abnormal activation map in high-risk relatives at the whole-brain or ROI level.
Figure 2. Subgroup analysis of abnormal functional activation pattern in high-risk relatives of patients with mood disorders. (A) Significant clusters identified in relatives of patients with BD; (B) Significant cluster identified in cognition-related experiments and emotional-related experiments; (C) Significant clusters identified in young and adult relatives.